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Small Molecules for Biology and Pharmacology. Click HERE to go directly to the screening set overview page.
Studying stem cell differentiation, probing or perturbing protein functions, in search of
novel kinase inhibitors, GPCR or ion-channel ligands, or studing allosteric modulation? Chances are you need small molecules as probes. But which ones? How to synthesize or get a hold of them?
The answer lies in our pre-plated chemlibraries.
Our structurally focussed plated screening sets combine well-known chemical lattices such as benzimidazoles,
quinolines, fused [6,7] ring systems, aryl- and benzylpiperazines, chiral pyrrolidines and
tetrahydroisoquinolines with various functional groups. The result is a high value screening
set of molecules that provides potential ligands against a wide variety of targets.
Our first generation compound libraries consist of:
By pre-plating our compounds into structurally distinct 96-well plates, we play into the concept of hit-rate within a series which states that 50-100 compounds are usually required in a series in order to be nearly certain of finding at least one active compound. (Ref: R.Milakantan, F. Immermann, K. Haraki, Combinatorial Chemistry & High Throughput Screening, 2002,5,105-110). This concept applies to general-purpose libraries - such as ours. Click HERE to go directly to the screening set overview page.
Benefits of our Structurally Focused Screening Libraries
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