BioQuadrant Inc.

80 compounds

This particular library consists of a single 96-well plate containing 80 purified sylfonyl-piperazines. Due to the relative small shape, structural constraints and simplicity of these molecules, this library can give you quick access to conformational and/or electronic requirements for the bioactivity of your target under investigation. At a price of $8/compound, it is our most affordable library. This library, as all others in our collection, was prepared in a dry film/powder format under nitrogen atmosphere in a 96-well plate to ensure long-term stability. All molecules are deposited as 2.5 micromoles per well. Simply dissolve the compounds in 250 microliter DMSO to obtain a concentration of 10mM. Columns 1 and 12 have been left empty.

160 compounds

This library consists of a diverse set of substituted quinolines (including KM11060) onto which alkyl- or aryl-sulfonyl-piperazine moieties are attached either directly, or indirectly through a carbonyl moiety. Quinolines themselves are privileged scaffolds. This collection of molecules is represented by 160 compounds, divided over two 96-well plates. Columns 1 and 12 on each plate have been left empty. Each plate can be purchased individually. Use this library as a starting basis for the discovery of novel anti-tumor compounds, anti-viral compounds, kinase inhibitors, ion channel modulators etc...

320 compounds

This extremely important class of molecules is represented by 320 unique compounds spread over 4 different 96-well plates. Each plate can be purchased individually. There is no overlap of structures between the different plates. This collection consists of benzimidazoles that have been functionalized at different positions with i.a hydrophobic and solvating groups. This collection can be applied to a wide variety of targets and therapeutic areas. Similar benzimidazoles are being used as beta-amyloid inhibitors, dopamine D3 receptor ligands, CCR5 antagonists, histamine H3 antagonists, analgesics, anti-fungals, neuroleptics, anti-virals, etc...

80 compounds

This library consists of a single 96-well plate containing 80 purified pyrrolidine-, tetra- hydroisoquinoline-, and amino-pyrrolidine- based benzodiazepinediones. Substituted 1,4-benzodiazepine-2,5-diones have shown usefulness as peptide mimetics capable of mimicing alpha-helix secondary structure, and this library can therefore be used to study protein-protein interactions.
Benzodiazepinediones themselves are a subset of 1,4-benzodiazepines, an important class of privileged templates. Besides having anticonvulsant, anxiolytic and antitumor properties, 1,4-benzodiazepine-2,5-diones have shown to be antagonists of the cholecystokinin (CCK), opioid and platelet glycoprotein IIb- IIIa receptors.

80 compounds

This compound collection consists of a single 96-well plate containing 80 chiral pyrrolidine-based 1,2,3-triazoles.
The triazole moiety carries aryl- or alkyl groups at position 4. The pyrrolidine moiety itself has been populated with "privileged structures" such as substituted piperazines, and/or sulfonyl groups. The result is a unique collection of small molecules for exploratory research. Given its size and composition, this collection sits at the interface between small-molecules and peptide mimetics.

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